PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3) is a relatively underexplored yet functionally significant protein with emerging importance in cancer biology, cellular stress response, and p53 signaling pathways. Encoded by the PHLDA3 gene on chromosome 1q31, this protein lacks enzymatic activity but plays a regulatory role by interacting with key signaling molecules. For...
The granzyme family of serine proteases plays a pivotal role in the immune system, particularly in mediating cytotoxic lymphocyte-induced cell death. Among these proteases, GZMK (Granzyme K) stands out for its unique biochemical properties and emerging immunological relevance. Unlike the more widely studied granzyme B, which induces apoptosis via caspase-dependent pathways, GZMK activates...
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